Dynamics of Engineered Artificial Membranes and Biosensors

Part I. Background: 1. Motivation and outline; 2. Biochemistry for engineers: a short primer; 3. Engineered artificial membranes; Part II. Building Engineered Membranes, Devices and Experimental Results: 4. Formation of engineered tethered membranes; 5. Ion-channel switch biosensor; 6. Physiochemical membrane platforms; 7. Experimental measurement methods for engineered membranes; Part III. Dynamic Models for Artificial Membranes: Atoms-to-Device: 8. Reaction-rate constrained models for engineered membranes; 9. Reaction-rate constrained models for the ICS biosensor; 10. Diffusion constrained continuum models of engineered membranes; 11. Electroporation models in engineered artificial membranes; 12. Electroporation measurements in engineered membranes; 13. Electrophysiological response of ion channels and cells; 14. Coarse-grained molecular dynamics; 15. All-atom molecular dynamics simulation models; 16. Closing summary for part III: from atoms to device; Appendices: Appendix A. Elementary primer on partial differential equations (PDE); Appendix B. Tutorial on coarse-grained molecular dynamics with peptides.

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• Engenharia biomédica
• Lípidos
• Biotecnologia